Abstract from the original 2012 Paris Baati Rat Study:
Countless studies showed that ESS60 and derivatives could have many potential biomedical applications. However, while several independent research groups showed that ESS60 has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of ESS60 and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of ESS60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of ESS60-olive oil solutions in an experimental model of CCl4 intoxication in rats strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved ESS60 is absorbed by the gastrointestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of ESS60 including cancer therapy, neurodegenerative disorders, and aging.
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Read the original publication here Original Paper.