Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential
biomedical applications. However, while several independent research groups showed that C(60) has no
acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery
the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C(60)
and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we
show that oral administration of C(60) dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7
mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their
lifespan.
The effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat
strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated
increases in oxidative stress. Pharmacokinetic studies show that dissolved C(60) is absorbed by the
gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the
fields of medicine and toxicology should open the way for the many possible -and waited for-
biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing.
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